Map11 Gene Summary [Mouse]
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in cilium assembly and regulation of cell population proliferation. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Predicted to be part of TRAPPII protein complex. Is expressed in liver; nervous system; neural retina; and thymus primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 25. Orthologous to human TRAPPC14 (trafficking protein particle complex subunit 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map11 |
| Official Name | microtubule associated protein 11 [Source:MGI Symbol;Acc:MGI:2385896] |
| Ensembl ID | ENSMUSG00000036948 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 11 |
| Synonyms | C7orf43, MAP11, MCPH25, RGD1305455, trafficking protein particle complex 14, trafficking protein particle complex subunit 14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-tubulin binding
- protein binding
- Domain of unknown function (DUF4707)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- centrosome
- midbody
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- centriolar satellite
- intracellular membrane-bounded organelle
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- alpha-tubulin binding