TRAPPC2L Gene Summary [Human]

This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Details

Type
Protein Coding
Official Symbol
TRAPPC2L
Official Name
trafficking protein particle complex 2 like [Source:HGNC Symbol;Acc:HGNC:30887]
Ensembl ID
ENSG00000167515
Bio databases IDs NCBI: 51693 Ensembl: ENSG00000167515
Aliases trafficking protein particle complex 2 like, trafficking protein particle complex subunit 2L
Synonyms 1810017G16Rik, HSPC176, LOC51693, PERRB, RGD1304906, Tca17, trafficking protein particle complex 2L, trafficking protein particle complex subunit 2L
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRAPPC2L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sedlin, N-terminal conserved region
  • protein binding
  • Longin-like domains

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • early-onset progressive encephalopathy with episodic rhabdomyolysis
  • colon carcinoma
  • colon epithelial cancer
  • rheumatoid arthritis
regulated by
  • T lymphocytes
  • CTNNB1
  • ROR2
  • hematopoietic progenitor cells
role in cell
  • DT-061 sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TRAPPC2L gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle coating
  • ER to Golgi vesicle-mediated transport
  • COPII vesicle coating

Cellular Component

Where in the cell the gene product is active
  • TRAPP complex
  • nucleus
  • perinuclear region of cytoplasm
  • cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol
  • endoplasmic reticulum

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.