DENND2A Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity. Involved in retrograde transport, endosome to Golgi. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DENND2A |
| Official Name | DENN domain containing 2A [Source:HGNC Symbol;Acc:HGNC:22212] |
| Ensembl ID | ENSG00000146966 |
| Bio databases IDs | |
| Aliases | DENN domain containing 2A |
| Synonyms | B930096L08Rik, C130031G22, DENN domain containing 2A, FAM31D, KIAA1277, mKIAA1277, RGD1306142 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DENND2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- protein binding
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DENND2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity