RAB35 Gene Summary [Human]
Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB35 |
| Official Name | RAB35, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9774] |
| Ensembl ID | ENSG00000111737 |
| Bio databases IDs | |
| Aliases | RAB35, member RAS oncogene family |
| Synonyms | 9530019H02RIK, H-ray, RAB1C, RAB35, member RAS oncogene family, RAY |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- small GTP-binding protein domain
- GDP binding
- phosphatidylinositol-4,5-bisphosphate binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
role in cell
- cell death
- outgrowth
- formation
- activation
- expression in
- invasion by
- phosphorylation in
- production in
- self-renewal
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- endocytic vesicle membrane
- cell surface
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytoplasmic bridges
- cytosol
- endosomal membrane
- growth cone
- endocytotic vesicle
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- clathrin-coated pits
- cellular protrusions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- protein localization in endosome
- cytokinesis after mitosis
- Rab protein signal transduction
- protein transport
- protein localization
- endosomal transport
- antigen processing and presentation
- plasma membrane to endosome transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- melanosome
- coated pit
- cytosol
- cell projection membrane
- endosome membrane
- clathrin-coated endocytic vesicle
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- GTPase activity
- GDP binding