RPS6KB2 Gene Summary [Human]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Details
| Type | Retained Intron |
| Official Symbol | RPS6KB2 |
| Official Name | ribosomal protein S6 kinase B2 [Source:HGNC Symbol;Acc:HGNC:10437] |
| Ensembl ID | ENSG00000175634 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase B2 |
| Synonyms | KLS, P70-beta, P70-beta-1, P70-beta-2, p70S6Kb, p70(S6K)-beta, p70 S6 kinase beta, p70 S6 kinase β, p70 S6k β, p70(S6K)-β, P70-β, P70-β-1, P70-β-2, ribosomal protein S6 kinase B2, ribosomal protein S6 kinase, polypeptide 2, Rps6k2b, S6K2, S6KB, S6K-beta, S6K-beta-2, S6KI(2), S6K-β, S6K-β-2, SRK, STK14B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- ribosomal protein S6 kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RPS6KB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Apelin Endothelial Signaling Pathway
- B Cell Receptor Signaling
- CNTF Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ERK5 Signaling
- Estrogen Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- IGF-1 Signaling
- IL-4 Signaling
- Insulin Receptor Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- Neuregulin Signaling
- NGF Signaling
- Opioid Signaling Pathway
- Ovarian Cancer Signaling
- p38 MAPK Signaling
- PTEN Signaling
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- TR/RXR Activation
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoxia
- growth failure
- limited systemic sclerosis
- osteogenesis imperfecta type III
- cyanosis
- bleeding
- infection by Vesicular stomatitis Indiana virus
role in cell
- proliferation
- expression in
- phosphorylation in
- growth
- apoptosis
- cell death
- production in
- survival
- accumulation in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- signal transduction
- TOR signaling cascade
- peptidyl-serine phosphorylation
- negative regulation of insulin receptor signaling pathway
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribosomal protein S6 kinase activity
- ATP binding
- protein kinase activity
- peptide binding
- protein serine/threonine kinase activity