LPAR4 Gene Summary [Human]
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Details
| Type | Processed Transcript |
| Official Symbol | LPAR4 |
| Official Name | lysophosphatidic acid receptor 4 [Source:HGNC Symbol;Acc:HGNC:4478] |
| Ensembl ID | ENSG00000147145 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 4 |
| Synonyms | 5730485F04Rik, GPR23, LPA4, LPA4 receptor, lysophosphatidic acid receptor 4, P2RY9, P2Y5-LIKE, P2Y9, RGD1563686 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPAR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- bioactive lipid receptor
- Cholecystokinin A receptor, N-terminal
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the LPAR4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
role in cell
- activation in
- migration
- formation
- growth
- invasion by
- aggregation
- morphology
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPAR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear body
- intracellular membrane-bounded organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- lysophosphatidic acid binding