BCL6 Gene Summary [Human]
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | BCL6 |
| Official Name | BCL6 transcription repressor [Source:HGNC Symbol;Acc:HGNC:1001] |
| Ensembl ID | ENSG00000113916 |
| Bio databases IDs | |
| Aliases | BCL6 transcription repressor |
| Synonyms | B cell leukaemia/lymphoma 6, B cell leukemia/lymphoma 6, BCL5, BCL6A, BCL6 transcription repressor, BCL6, transcription repressor, LAZ3, ZBTB27, zinc finger protein 51, ZNF51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- acetylation site
- DNA binding domain
- nucleic acid binding
- BTB_POZ
- alpha helix
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- beta strand or sheet
- PEST domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the BCL6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- major depression
- Alzheimer disease
- cancer
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- cell cycle progression
- growth
- apoptosis
- survival
- proliferation
- production in
- expression in
- killing
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Golgi Apparatus
- nuclear foci
- interchromatin space
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
- DNA replication foci
- chromatin
- replication fork
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCL6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T-helper 2 cell differentiation
- negative regulation of Rho protein signal transduction
- negative regulation of plasma cell differentiation
- pyramidal neuron differentiation
- protein localization
- positive regulation of neuron differentiation
- transcription from RNA polymerase II promoter
- regulation of immune system process
- negative regulation of Notch signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of regulatory T cell differentiation
- inflammatory response
- negative regulation of mononuclear cell proliferation
- regulation of germinal center formation
- regulation of cell differentiation
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- plasma cell differentiation
- isotype switching to IgE isotypes
- negative regulation of mast cell cytokine production
- regulation of immune response
- negative regulation of cellular senescence
- cell-matrix adhesion
- regulation of T cell proliferation
- spermatogenesis
- cell morphogenesis
- B cell proliferation
- erythrocyte development
- Rho protein signal transduction
- response to DNA damage stimulus
- regulation of cell proliferation
- cell motility
- germinal center formation
- type 2 immune response
- T-helper 2 cell differentiation
- regulation of memory T cell differentiation
- negative regulation of cell-matrix adhesion
- heterochromatin assembly
- positive regulation of apoptotic process
- negative regulation of B cell apoptotic process
- regulation of inflammatory response
- positive regulation of B cell proliferation
- regulation of cytokine production
- negative regulation of isotype switching to IgE isotypes
- actin cytoskeleton organization
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- paraspeckles
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- metal ion binding
- intronic transcription regulatory region sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding