AGFG1 Gene Summary [Human]
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | AGFG1 |
| Official Name | ArfGAP with FG repeats 1 [Source:HGNC Symbol;Acc:HGNC:5175] |
| Ensembl ID | ENSG00000173744 |
| Bio databases IDs | |
| Aliases | ArfGAP with FG repeats 1 |
| Synonyms | ArfGAP with FG repeats 1, C130049H11Rik, D730048C23RIK, Hiv1 rev binding, HRB, LOC285086, RAB, RIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGFG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FG repeat
- Putative GTP-ase activating proteins for the small GTPase, ARF
- NPF motif
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- systemic lupus erythematosus
- silicosis
- pervasive developmental disorder
- airway hyperresponsiveness
role in cell
- accumulation in
- formation
- differentiation
- formation in
- development
- assembly
- accumulation
- organization
- differentiation in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- outer membranes
- cytosol
- nuclear pores
- cytoplasmic vesicles
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGFG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- acrosome assembly
- spermatid nucleus differentiation
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- cytosol
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- metal ion binding
- GTPase activator activity