POLDIP2 Gene Summary [Human]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | POLDIP2 |
| Official Name | DNA polymerase delta interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:23781] |
| Ensembl ID | ENSG00000004142 |
| Bio databases IDs | |
| Aliases | DNA polymerase delta interacting protein 2 |
| Synonyms | 1300003F06Rik, DNA polymerase delta interacting protein 2, DNA polymerase δ interacting protein 2, p38, PDIP38, polymerase (DNA-directed), delta interacting protein 2, polymerase (DNA-directed), δ interacting protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLDIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemimethylated DNA-binding protein YccV like
- protein binding activity, bridging
- ApaG domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- focal adhesions
- Nucleus
- Mitochondria
- midbody
- intercellular junctions
- cell-cell contacts
- mitochondrial matrix
- mitochondrial nucleoids
- actin stress fibers
- mitotic spindle
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLDIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of focal adhesion assembly
- negative regulation of macroautophagy
- positive regulation of mitotic cell cycle
- mitochondrion organization
- error-free translesion synthesis
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell-cell junction
- mitotic spindle
- mitochondrial matrix
- mitochondrion
- midbody
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding