SLC25A37 Gene Summary [Human]
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC25A37 |
| Official Name | solute carrier family 25 member 37 [Source:HGNC Symbol;Acc:HGNC:29786] |
| Ensembl ID | ENSG00000147454 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 37, mitoferrin, Mitoferrin-1, Mitochondrial iron transporter 1, Mitochondrial solute carrier protein |
| Synonyms | 1700020E22Rik, 4930513O14Rik, 4930526G11Rik, C330015G08Rik, Frascati, HT015, MFRN, MFRN1, mitoferrin, MSC, MSCP, PRO1278, PRO1584, PRO2217, RGD1359361, solute carrier family 25 member 37, solute carrier family 25, member 37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC25A37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron transporter
- Mitochondrial carrier protein
- iron ion transporter
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the SLC25A37 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- nonalcoholic fatty liver disease
- hypothyroidism
- anemia
regulates
- Cytochrome bc1
- heavy metal
- succinate dehydrogenase
- hemoglobin
- SLC25A37
- ATP synthase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC25A37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hemoglobin biosynthetic process
- mitochondrial iron ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion transmembrane transporter activity
- ferrous iron transmembrane transporter activity