FBXO10 Gene Summary [Human]
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXO10 |
| Official Name | F-box protein 10 [Source:HGNC Symbol;Acc:HGNC:13589] |
| Ensembl ID | ENSG00000147912 |
| Bio databases IDs | |
| Aliases | F-box protein 10 |
| Synonyms | F-box protein 10, FBX10, Gm634, PRMT11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- Right handed beta helix region
- F-box domain superfamily
- Periplasmic copper-binding protein (NosD)
- F-box-like
- Protein of unknown function (DUF1565)
- parallel beta-helix repeat (two copies)
- enzyme
- protein binding
- Domain present in carbohydrate binding proteins and sugar hydrolses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding