PTGES2 Gene Summary [Human]
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | PTGES2 |
| Official Name | prostaglandin E synthase 2 [Source:HGNC Symbol;Acc:HGNC:17822] |
| Ensembl ID | ENSG00000148334 |
| Bio databases IDs | |
| Aliases | prostaglandin E synthase 2 |
| Synonyms | 0610038H10Rik, C9orf15, GBF-1, MPGES2, PGE2, PGES2, prostaglandin E synthase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGES2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- transcription regulator
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- lyase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
- heme binding
- DNA binding
- prostaglandin-E synthase
Pathways
Biological processes and signaling networks where the PTGES2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- edema
- hypersensitivity reaction type I
regulates
- lipid
- prostaglandin E2
- IRF9
- prostanoid
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- membrane fraction
- azurophil granule lumen
- Extracellular Space
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGES2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- secretion
- cyclooxygenase pathway
- positive regulation of transcription, DNA-dependent
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- mitochondrion
- cytosol
- Golgi membrane
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- 12-hydroxyheptadecatrienoic acid synthase activity
- DNA binding
- protein binding
- glutathione binding
- prostaglandin-E synthase activity
- lyase activity
- heme binding