EXOSC10 Gene Summary [Human]
Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EXOSC10 |
| Official Name | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] |
| Ensembl ID | ENSG00000171824 |
| Bio databases IDs | |
| Aliases | exosome component 10, polymyositis/scleroderma autoantigen 2 (100kD) |
| Synonyms | Autoantigen PM/Scl 2, exosome component 10, p2, p3, p4, PMSCL, PM/Scl-100, PMSCL2, RRP6, Rrp6p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOSC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 3'-5' exoribonuclease
- HRDC domain
- Helicase and RNase D C-terminal
- PMC2NT (NUC016) domain
- exoribonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- protein binding
- ribonuclease D
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- expression in
- accumulation in
- processing in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pre-ribosome
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXOSC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- nuclear-transcribed mRNA catabolic process
- RNA processing
- rRNA processing
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- RNA catabolic process
- polyadenylation-dependent snoRNA 3'-end processing
- nuclear polyadenylation-dependent antisense transcript catabolic process
- maturation of 5.8S rRNA
- nuclear polyadenylation-dependent rRNA catabolic process
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- nuclear polyadenylation-dependent snoRNA catabolic process
- histone mRNA catabolic process
- ribosomal small subunit biogenesis
- CUT catabolic process
- nuclear polyadenylation-dependent CUT catabolic process
- nuclear mRNA surveillance
- nuclear polyadenylation-dependent snRNA catabolic process
- negative regulation of telomere maintenance via telomerase
- nuclear polyadenylation-dependent tRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nuclear exosome (RNase complex)
- small-subunit processome
- nucleus
- euchromatin
- cytoplasm
- membrane
- cytosol
- nucleolus
- nucleoplasm
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- telomeric RNA binding
- metal ion binding
- single-stranded RNA binding
- exoribonuclease activity