MAP3K1 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K1 |
| Official Name | mitogen-activated protein kinase kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6848] |
| Ensembl ID | ENSG00000095015 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 1 |
| Synonyms | LOC100912399, MAPK, MAPKKK1, MEKK, MEKK 1, MEK KINASE, MEK KINASE 1, mitogen-activated protein kinase kinase kinase 1, Raf, SRXY6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- caspase cleavage site
- Protein kinase domain
- Sh3 domain binding motif
- cytoskeletal protein binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Tyrosine kinase, catalytic domain
- sphingolipid binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- JUN kinase kinase kinase
- JUN kinase binding
- Ring finger domain
- protein binding
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- TOG-like domain
- binding protein
- Protein Kinases, catalytic domain
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
Pathways
Biological processes and signaling networks where the MAP3K1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- Ceramide Signaling
- EGF Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- HGF Signaling
- IL-1 Signaling
- Natural Killer Cell Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- NGF Signaling
- PDGF Signaling
- Protein Kinase A Signaling
- Rac Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renin-Angiotensin Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- Type II Diabetes Mellitus Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- epithelial cancer
- congestive heart failure
- 46,XY sex reversal type 6
- serous ovarian adenocarcinoma
- serous ovarian cancer
- hereditary disorder
- prostatic carcinoma
role in cell
- expression in
- adhesion
- phosphorylation in
- apoptosis
- formation
- chemotaxis
- invasion by
- growth
- activation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- actin filaments
- intercellular junctions
- cytosol
- membrane ruffles
- cortical actin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to mechanical stimulus
- Fc-epsilon receptor signaling pathway
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- zinc ion binding
- protein binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity