GRIK4 Gene Summary [Human]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | GRIK4 |
| Official Name | glutamate ionotropic receptor kainate type subunit 4 [Source:HGNC Symbol;Acc:HGNC:4582] |
| Ensembl ID | ENSG00000149403 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor kainate type subunit 4 |
| Synonyms | 6330551K01Rik, EAA1, GluK4, GluK4-2, GluRgamma1, glutamate ionotropic receptor kainate type subunit 4, glutamate receptor, ionotropic, kainate 4, GRIK, KA-1, Ka1r, LOC100293636 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kainate selective glutamate receptor
- Receptor family ligand binding region
- Type 1 periplasmic binding fold superfamily
- Ligated ion channel L-glutamate- and glycine-binding site
- Type 2 periplasmic binding fold superfamily
- ionotropic glutamate receptor
- ligand-gated ion channel
- protein binding
- ion channel
- Bacterial extracellular solute-binding proteins, family 3
Pathways
Biological processes and signaling networks where the GRIK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- hypothyroidism
- major depression
- stuttering
- idiopathic pulmonary fibrosis
- suicide attempt
- small vessel disease stroke
- attention deficit hyperactivity disorder
- appendicitis
regulates
- L-glutamic acid
- GRIK4
- ion
- citalopram
role in cell
- depolarization
- action potential in
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- Nucleus
- presynaptic membrane
- postsynaptic membrane
- endosomal compartment
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- ion transmembrane transport
- regulation of synaptic transmission
- synaptic transmission
- ionotropic glutamate receptor signaling pathway
- glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- kainate selective glutamate receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- kainate selective glutamate receptor activity