REST Gene Summary [Human]
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]
Details
| Type | Protein Coding |
| Official Symbol | REST |
| Official Name | RE1 silencing transcription factor [Source:HGNC Symbol;Acc:HGNC:9966] |
| Ensembl ID | ENSG00000084093 |
| Bio databases IDs | |
| Aliases | RE1 silencing transcription factor, neuron-restrictive silencer factor |
| Synonyms | 2610008J04RIK, D14MGI11, DFNA27, GINGF5, HGF5, NRSF, RE1-silencing transcription factor, WT6, XBR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- DNA binding domain
- nucleic acid binding
- C2H2-type zinc-finger domain
- transcription factor binding
- inhibitory domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- binding protein
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the REST gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- renal cancer
- autosomal dominant deafness type 27
- susceptibility to Wilms tumor 6
- myocardial infarction
- growth failure
- progressive hearing impairment
- gingival fibromatosis type 5
- gingival fibromatosis type 1
role in cell
- activation in
- migration
- expression in
- recruitment in
- apoptosis
- proliferation
- survival
- stabilization in
- cell cycle progression
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear rim
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- negative regulation of cortisol biosynthetic process
- negative regulation of cell proliferation
- negative regulation of neuron differentiation
- positive regulation of programmed cell death
- positive regulation of neuron differentiation
- negative regulation of insulin secretion
- positive regulation of transcription from RNA polymerase II promoter
- neuronal stem cell maintenance
- regulation of osteoblast differentiation
- hemopoietic progenitor cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- response to ischemia
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- negative regulation of amniotic stem cell differentiation
- cellular response to electrical stimulus
- negative regulation of aldosterone biosynthetic process
- neurological system process
- regulation of transcription, DNA-dependent
- negative regulation of calcium ion-dependent exocytosis
- cardiac muscle cell myoblast differentiation
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of gene expression
- negative regulation of dense core granule biogenesis
- cellular response to glucocorticoid stimulus
- positive regulation of apoptotic process
- cellular response to xenobiotic stimulus
- negative regulation of neurogenesis
- negative regulation of mesenchymal stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcriptional repressor complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding