FER Gene Summary [Human]
The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | FER |
| Official Name | FER tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3655] |
| Ensembl ID | ENSG00000151422 |
| Bio databases IDs | |
| Aliases | FER tyrosine kinase, phosphoprotein NCP94, protein phosphatase 1, regulatory subunit 74 |
| Synonyms | C330004K01Rik, FerT, Fert2, FER tyrosine kinase, Flk, Flk retired, PPP1R74, Protein tyrosine kinase fer, TYK3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FER often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein kinase
- lipid binding
- Protein tyrosine and serine/threonine kinase
- epidermal growth factor receptor binding
- Fes/CIP4, and EFC/F-BAR homology domain
- non-membrane spanning protein tyrosine kinase
- coiled-coil domain
- protein binding
- enzyme
- protein-tyrosine kinase
- Protein kinase domain
- Bin/Amphiphysin/Rvs domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- p120-catenin binding domain
- protein phosphatase 1 binding
- Protein Kinases, catalytic domain
- tyrosine kinase domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the FER gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- coronary artery disease
- metastatic lung adenocarcinoma
- advanced non-small cell lung cancer
- squamous cell lung cancer
- metastatic non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- advanced lung squamous cell carcinoma
- advanced large cell lung carcinoma
role in cell
- apoptosis
- expression in
- migration
- phosphorylation in
- activation in
- formation
- proliferation
- chemotaxis
- adhesion
- emigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cell junction
- cell periphery
- actin cytoskeleton
- cell cortex
- Nucleus
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- growth cone
- chromatin
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FER gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- insulin receptor signaling pathway
- positive regulation of cell proliferation
- Fc-epsilon receptor signaling pathway
- protein autophosphorylation
- Sertoli cell development
- cell adhesion
- regulation of epidermal growth factor receptor signaling pathway
- protein phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- chemotaxis
- seminiferous tubule development
- cytokine-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- interleukin-6-mediated signaling pathway
- cellular response to macrophage colony-stimulating factor stimulus
- intracellular signal transduction
- Kit signaling pathway
- germ cell development
- regulation of lamellipodium assembly
- tyrosine phosphorylation of STAT protein
- diapedesis
- platelet-derived growth factor receptor signaling pathway
- microtubule cytoskeleton organization
- regulation of protein phosphorylation
- cell-cell adhesion mediated by cadherin
- positive regulation of actin filament polymerization
- extracellular matrix-cell signaling
- response to platelet-derived growth factor stimulus
- response to lipopolysaccharide
- adherens junction assembly
- cellular response to reactive oxygen species
- actin cytoskeleton organization
- negative regulation of mast cell activation involved in immune response
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- chromatin
- plasma membrane
- internal side of plasma membrane
- nucleus
- adherens junction
- cytoplasm
- cell cortex
- actin cytoskeleton
- cell junction
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- epidermal growth factor receptor binding
- lipid binding
- protein phosphatase 1 binding