SP110 Gene Summary [Human]
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SP110 |
| Official Name | SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401] |
| Ensembl ID | ENSG00000135899 |
| Bio databases IDs | |
| Aliases | SP110 nuclear body protein |
| Synonyms | 5031415C07RIK, 5830484A20RIK, IFI41, IFI75, IPR1, NUCLEAR PHOSPHOPROTEIN, SP110 nuclear body protein, VODI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SP110 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell division protein FtsN
- KDWK domain
- PHD zinc finger
- SP100-like domain
- HCV core protein binding domain
- PHD finger superfamily
- Bromodomain
- SAND domain
- HSR domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- hepatic veno-occlusive disease with immunodeficiency
- chronic lymphocytic leukemia
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- infection by HIV-1
- productive infection by HIV-1
role in cell
- expression in
- growth
- damage in
- downregulation in
- recruitment in
- upregulation in
- missegregation in
- homologous recombination repair in
- replication in
- missegregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SP110 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity