DPYSL4 Gene Summary [Human]
Enables filamin binding activity. Predicted to be involved in nervous system development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DPYSL4 |
| Official Name | dihydropyrimidinase like 4 [Source:HGNC Symbol;Acc:HGNC:3016] |
| Ensembl ID | ENSG00000151640 |
| Bio databases IDs | |
| Aliases | dihydropyrimidinase like 4 |
| Synonyms | AC174642.1, CRMP-3, dihydropyrimidinase-like 4, DPY4, DPYS4, DRP-4, Tuc-3a, ULIP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPYSL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- dihydroorotase, multifunctional complex type
- Amidohydrolase family
- phosphoprotein binding
- enzyme
- protein binding
- metallo-dependent_hydrolases
- D-hydantoinase
Pathways
Biological processes and signaling networks where the DPYSL4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- breast cancer
- organismal death
- metastasis
- atrial fibrillation
- pancreatic cancer
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- cervical cancer
regulates
- Mitochondrial ETC 1
- adenosine triphosphate
- oxygen
- Cytochrome bc1
- cytochrome-c oxidase
- DPYSL4
role in cell
- binding in
- quantity
- production in
- morphology
- invasion by
- length
- consumption in
- branching
- long-term potentiation
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPYSL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine base catabolic process
- nervous system development
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- protein binding
- dihydropyrimidinase activity
- filamin binding