ACSL1 Gene Summary [Human]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | ACSL1 |
| Official Name | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] |
| Ensembl ID | ENSG00000151726 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase long chain family member 1, lignoceroyl-CoA synthase, long-chain fatty-acid-coenzyme A ligase 1 |
| Synonyms | ACAS, Acas1, ACS, ACS1, ACYL-COA SYNTHETASE, Acyl-coa synthetase 5, acyl-CoA synthetase long-chain family member 1, COAA, FACL1, FACL2, FACS, Facs1, Fatty acid coa ligase 2, Fatty Acid Coenzyme A Ligase, Long Chain 2, LACS, LACS 1, LACS2, Long Chain Acyl-CoA Synthetase 2, Long chain fatty acid CoA synthase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACSL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- long-chain-fatty-acid-CoA ligase
- arachidonate-CoA ligase
- AMP-binding enzyme
- acyl-CoA ligase (AMP-forming), exosortase A-associated
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- acetate-CoA ligase
- enzyme
- amino acid adenylation domain
- phytanate-CoA ligase
Pathways
Biological processes and signaling networks where the ACSL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- obesity
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- breast cancer
- diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- metabolic syndrome X
- dilated cardiomyopathy
role in cell
- phosphorylation in
- accumulation in
- ferroptosis
- activation in
- apoptosis
- expression in
- production in
- proliferation
- quantity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial outer membrane
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACSL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- lipid biosynthetic process
- xenobiotic catabolic process
- response to nutrient
- response to organic cyclic compound
- very long-chain fatty acid metabolic process
- long-chain fatty acid metabolic process
- positive regulation of plasma membrane long-chain fatty acid transport
- fatty acid transport
- triglyceride biosynthetic process
- long-chain fatty-acyl-CoA biosynthetic process
- response to oleic acid
- adiponectin-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- mitochondrion
- membrane
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- pristanate-CoA ligase activity
- ATP binding
- protein serine/threonine kinase activator activity
- phytanate-CoA ligase activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity