FBXO4 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | FBXO4 |
| Official Name | F-box protein 4 [Source:HGNC Symbol;Acc:HGNC:13583] |
| Ensembl ID | ENSG00000151876 |
| Bio databases IDs | |
| Aliases | F-box protein 4 |
| Synonyms | 1700096C12RIK, F-box protein 4, FBX4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- digestive system cancer
- abdominal cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- proliferation
- accumulation in
- expression in
- migration
- growth
- degradation in
- cell cycle progression
- response by
- replicative senescence
- senescence in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- negative regulation of protein localization to nucleus
- protein polyubiquitination
- cellular senescence
- posttranscriptional regulation of gene expression
- protein destabilization
- regulation of protein stability
- negative regulation of fibroblast proliferation
- positive regulation of protein ubiquitination
- positive regulation of telomere maintenance via telomerase
- cellular response to ionizing radiation
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of DNA damage checkpoint
- common myeloid progenitor cell proliferation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- protein homodimerization activity