Fbxo4 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity and ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; protein destabilization; and regulation of macromolecule metabolic process. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo4 |
| Official Name | F-box protein 4 [Source:MGI Symbol;Acc:MGI:2146220] |
| Ensembl ID | ENSMUSG00000022184 |
| Bio databases IDs | |
| Aliases | F-box protein 4 |
| Synonyms | 1700096C12RIK, F-box protein 4, FBX4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- protein homodimerization
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- digestive system cancer
- abdominal cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- proliferation
- accumulation in
- expression in
- migration
- growth
- degradation in
- cell cycle progression
- response by
- replicative senescence
- senescence in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- negative regulation of protein localization to nucleus
- protein polyubiquitination
- cellular senescence
- posttranscriptional regulation of gene expression
- protein destabilization
- regulation of protein stability
- negative regulation of fibroblast proliferation
- positive regulation of protein ubiquitination
- positive regulation of telomere maintenance via telomerase
- cellular response to ionizing radiation
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of DNA damage checkpoint
- common myeloid progenitor cell proliferation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- protein homodimerization activity