KCNE4 Gene Summary [Human]
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KCNE4 |
| Official Name | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] |
| Ensembl ID | ENSG00000152049 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily E regulatory subunit 4 |
| Synonyms | LOC108351957, MIRP3, potassium voltage-gated channel, Isk-related subfamily, gene 4, potassium voltage-gated channel subfamily E regulatory subunit 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNE4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- ion channel binding
- protein binding
- potassium channel inhibitor
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- adenomyosis
- HER2 negative hormone receptor negative breast cancer
- cardioembolic stroke
- childhood acute lymphoblastic leukemia
- glioblastoma
- glioblastoma cancer
- acute lymphoblastic leukemia
- hepatitis B
role in cell
- colony formation by
- migration
- invasion by
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNE4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of action potential
- regulation of ventricular cardiac muscle cell action potential
- regulation of ventricular cardiomyocyte membrane repolarization
- regulation of heart rate by cardiac conduction
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- delayed rectifier potassium channel activity
- potassium channel regulator activity
- ion channel binding