ALG11 Gene Summary [Human]
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | ALG11 |
| Official Name | ALG11 alpha-1,2-mannosyltransferase [Source:HGNC Symbol;Acc:HGNC:32456] |
| Ensembl ID | ENSG00000253710 |
| Bio databases IDs | |
| Aliases | ALG11 alpha-1,2-mannosyltransferase, GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase |
| Synonyms | AI849156, ALG11 alpha-1,2-mannosyltransferase, ALG11, alpha-1,2-mannosyltransferase, ALG11 α-1,2-mannosyltransferase, ALG11, α-1,2-mannosyltransferase, AW492253, B230397C21, CDG1P, GT8, LOC100505039, Mmat-4(5), RGD1564725 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALG11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- glycolipid 2-alpha-mannosyltransferase
- enzyme
- protein binding
- ALG11 mannosyltransferase N-terminus
- Glycosyl transferases group 1
- alpha-1,2-mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALG11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligosaccharide-lipid intermediate biosynthetic process
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
- alpha-1,2-mannosyltransferase activity