Kcne4 Gene Summary [Mouse]
Predicted to enable potassium channel activity; potassium channel inhibitor activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including potassium ion export across plasma membrane; regulation of heart rate by cardiac conduction; and ventricular cardiac muscle cell action potential. Predicted to be located in apical plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in heart and heart ventricle. Orthologous to human KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcne4 |
| Official Name | potassium voltage-gated channel, Isk-related subfamily, gene 4 [Source:MGI Symbol;Acc:MGI:1891125] |
| Ensembl ID | ENSMUSG00000047330 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, Isk-related subfamily, gene 4 |
| Synonyms | LOC108351957, MIRP3, potassium voltage-gated channel, Isk-related subfamily, gene 4, potassium voltage-gated channel subfamily E regulatory subunit 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcne4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- ion channel binding
- protein binding
- potassium channel inhibitor
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- adenomyosis
- HER2 negative hormone receptor negative breast cancer
- cardioembolic stroke
- childhood acute lymphoblastic leukemia
- glioblastoma
- glioblastoma cancer
- acute lymphoblastic leukemia
- hepatitis B
role in cell
- colony formation by
- migration
- invasion by
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcne4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of action potential
- regulation of ventricular cardiac muscle cell action potential
- regulation of ventricular cardiomyocyte membrane repolarization
- regulation of heart rate by cardiac conduction
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- delayed rectifier potassium channel activity
- potassium channel regulator activity
- ion channel binding