GEMIN6 Gene Summary [Human]
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | GEMIN6 |
| Official Name | gem nuclear organelle associated protein 6 [Source:HGNC Symbol;Acc:HGNC:20044] |
| Ensembl ID | ENSG00000152147 |
| Bio databases IDs | |
| Aliases | gem nuclear organelle associated protein 6 |
| Synonyms | 2610019B15Rik, 2810470M17Rik, gem (nuclear organelle) associated protein 6, gem nuclear organelle associated protein 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GEMIN6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sm and related proteins
- Gemin6 Sm-like domain
- Gemin6 C-terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- gems
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GEMIN6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- SMN-Sm protein complex
- cytosol
- SMN complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding