OBI1 Gene Summary [Human]
Enables chromatin binding activity and ubiquitin-protein transferase activity. Involved in protein autoubiquitination; protein monoubiquitination; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | OBI1 |
| Official Name | ORC ubiquitin ligase 1 [Source:HGNC Symbol;Acc:HGNC:20308] |
| Ensembl ID | ENSG00000152193 |
| Bio databases IDs | |
| Aliases | ORC ubiquitin ligase 1 |
| Synonyms | 2610206B13Rik, 2810449K13Rik, C13orf7, Obl1, ORC ubiquitin ligase 1, RGD1564706, RNF219 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OBI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- chromatin binding
- enzyme
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OBI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of DNA replication
- protein monoubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- chromatin
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- chromatin binding