LRRK2 Gene Summary [Human]
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LRRK2 |
| Official Name | leucine rich repeat kinase 2 [Source:HGNC Symbol;Acc:HGNC:18618] |
| Ensembl ID | ENSG00000188906 |
| Bio databases IDs | |
| Aliases | leucine rich repeat kinase 2, dardarin |
| Synonyms | 4921513O20RIK, 9330188B09Rik, AURA17, cI-46, D630001M17RIK, DARDARIN, DKFZP434H2111, FLJ45829, Gm927, leucine-rich repeat kinase 2, PARK8, RIPK7, ROCO2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- protein serine/threonine kinase
- protein kinase
- enzyme inhibitor activity
- Leucine rich repeat
- clathrin binding
- GTPase activator
- C-terminal of Roc, COR, domain
- Leucine Rich repeats (2 copies)
- Protein kinase domain
- mitogen-activated protein kinase kinase kinase domain
- identical protein binding
- leucine-rich repeat
- receptor signaling complex scaffold protein
- tubulin binding
- actin binding
- syntaxin-1 binding
- ion channel binding
- MLK-like domain
- Ras of Complex, Roc, domain of DAPkinase
- Tyrosine kinase, catalytic domain
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- protein kinase A binding
- Protein kinase (unclassified specificity)
- Roc domain
- protein phosphatase 1 regulatory subunit 42
- Protein tyrosine and serine/threonine kinase
- GTPase
- JUN kinase kinase kinase
- enzyme binding
- protein binding
- magnesium ion binding
- MAP kinase kinase kinase
- kinase
- GTP binding
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- microtubule binding
- binding protein
- small GTP-binding protein domain
- Protein Kinases, catalytic domain
- GTPase domain
- protein homodimerization
- COR domain
Pathways
Biological processes and signaling networks where the LRRK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Parkinson disease
- Alzheimer disease
- neurodegeneration
- inflammatory bowel disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- familial Parkinson disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- phosphorylation in
- expression in
- migration
- transmembrane potential
- deposition in
- activation in
- production in
- growth
- apoptosis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- amphisome
- extranuclear space
- intracellular membrane-bounded organelle
- perinuclear region
- outer membranes
- cellular membrane
- Plasma Membrane
- basal bodies
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- cytosol
- microdomains
- trans Golgi network
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrial inner membrane
- nucleoplasm
- nuclear envelope
- synaptic vesicles
- growth cone
- neurites
- synapse
- cytoplasmic vesicles
- autolysosomes
- membrane rafts
- microvilli
- perikaryon
- axons
- dendrites
- axon terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- exploration behavior
- regulation of kidney size
- locomotory exploration behavior
- positive regulation of dopamine receptor signaling pathway
- determination of adult lifespan
- protein localization
- positive regulation of programmed cell death
- protein autophosphorylation
- JNK cascade
- striatum development
- negative regulation of protein binding
- neuromuscular junction development
- negative regulation of neuron projection development
- autophagy
- regulation of protein kinase A signaling cascade
- positive regulation of protein ubiquitination
- positive regulation of tumor necrosis factor production
- calcium-mediated signaling
- mitochondrion localization
- regulation of synaptic transmission, glutamatergic
- intracellular signal transduction
- regulation of dendritic spine morphogenesis
- negative regulation of GTPase activity
- regulation of excitatory postsynaptic membrane potential
- regulation of lysosomal lumen pH
- regulation of branching morphogenesis of a nerve
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of mitochondrial fission
- Rho protein signal transduction
- endoplasmic reticulum organization
- endocytosis
- regulation of dopamine receptor signaling pathway
- positive regulation of autophagy
- regulation of membrane potential
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of protein kinase activity
- protein import into nucleus
- cellular response to manganese ion
- regulation of autophagy
- negative regulation of macroautophagy
- peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- cellular response to reactive oxygen species
- peptidyl-threonine phosphorylation
- positive regulation of MAP kinase activity
- regulation of locomotion
- Golgi organization
- regulation of neuron maturation
- tangential migration from the subventricular zone to the olfactory bulb
- neuron projection morphogenesis
- GTP metabolic process
- negative regulation of excitatory postsynaptic membrane potential
- protein phosphorylation
- olfactory bulb development
- MAPK cascade
- response to oxidative stress
- regulation of ER to Golgi vesicle-mediated transport
- protein localization in mitochondrion
- negative regulation of protein processing
- regulation of canonical Wnt receptor signaling pathway
- regulation of reactive oxygen species metabolic process
- canonical Wnt receptor signaling pathway
- phosphorylation
- regulation of mitochondrial depolarization
- lysosome organization
- signal transduction
- spermatogenesis
- positive regulation of synaptic vesicle endocytosis
- cellular response to starvation
- mitochondrion organization
- regulation of protein stability
- intracellular distribution of mitochondria
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- regulation of synaptic vesicle exocytosis
- protein localization to endoplasmic reticulum exit site
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- external side of mitochondrial outer membrane
- Golgi apparatus
- Golgi membrane
- neuronal cell body
- perikaryon
- neuron projection
- Golgi-associated vesicle
- growth cone
- endoplasmic reticulum membrane
- dendrite
- trans-Golgi network
- endosome
- extracellular vesicular exosome
- terminal button
- microvillus
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- cytosol
- axon
- endoplasmic reticulum
- mitochondrial outer membrane
- plasma membrane
- mitochondrial inner membrane
- lysosome
- extracellular space
- mitochondrial membrane
- cytoskeleton
- mitochondrial matrix
- cytoplasm
- dendrite cytoplasm
- mitochondrion
- endoplasmic reticulum exit site
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- GTP-dependent protein kinase activity
- GTPase activator activity
- magnesium ion binding
- GTP binding
- ATP binding
- GTPase activity
- identical protein binding
- protein homodimerization activity
- protein kinase activity
- SNARE binding
- protein serine/threonine kinase activity
- ion channel binding
- microtubule binding
- protein binding
- actin binding
- syntaxin-1 binding
- JUN kinase kinase kinase activity
- small GTPase binding
- clathrin binding
- MAP kinase kinase kinase activity
- kinase activity
- receptor signaling complex scaffold activity
- protein kinase A binding