FBXL2 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Processed Transcript |
| Official Symbol | FBXL2 |
| Official Name | F-box and leucine rich repeat protein 2 [Source:HGNC Symbol;Acc:HGNC:13598] |
| Ensembl ID | ENSG00000153558 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 2 |
| Synonyms | 2810423A21Rik, FBL2, FBL3, F-box and leucine-rich repeat protein 2, F-box/LRR-repeat protein 2, RGD1562243 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- phosphoinositide 3-kinase binding
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- protein phosphatase binding
- F-box-like
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lymphoblastic leukemia
- colorectal cancer
- acute myeloid leukemia
- hypertension
role in cell
- growth
- expression in
- apoptosis
- phosphorylation in
- migration
- differentiation
- proliferation
- quantity
- G2/M phase
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- regulation of protein kinase B signaling cascade
- regulation of autophagy
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of inflammatory response
- protein monoubiquitination
- negative regulation of NLRP3 inflammasome complex assembly
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- protein phosphatase binding