UBE2D3
UBE2D3 Gene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | UBE2D3 |
| Official Name | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] |
| Ensembl ID | ENSG00000109332 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 D3 |
| Synonyms | 1100001F19RIK,9430029A22Rik,E2(17)KB3,LOC100128180,UBC4/5,UBCH5C,UBIQUITIN CONJUGATING ENZYME E2D3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2D3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RNF126
- RSPRY1
- RNF11
- ganglioside GD3
- RNF111
- UBC
- BRCA1
- RNF185
- BARD1
- FBXL2
disease
- migraines
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- overall survival
regulated by
- RNF7
- CUL1
- SNAI2
- CUL5
- lipopolysaccharide
- CDKN2A-AS1
- USP18
- mir-23 (includes others)
- SBDS
- CRP
regulates
- CASP3
- TP53
- RNF126
- MDM2
- BIRC6
- DNA promoter
- DNA endogenous promoter
- CCND1
- PSMC3
- TRIM21
role in cell
- degradation in
- growth
- differentiation
- proliferation
- formation
- cell cycle progression
- invasiveness
- phagocytosis
- phagocytosis by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the UBE2D3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA repair
- protein modification process
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein polyubiquitination
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic process
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytosol
- endosome membrane
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding