Fbxl2 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and regulation of inflammatory response. Acts upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Fbxl2 |
| Official Name | F-box and leucine-rich repeat protein 2 [Source:MGI Symbol;Acc:MGI:1919429] |
| Ensembl ID | ENSMUSG00000032507 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 2 |
| Synonyms | 2810423A21Rik, FBL2, FBL3, F-box and leucine-rich repeat protein 2, F-box/LRR-repeat protein 2, RGD1562243 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- phosphoinositide 3-kinase binding
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- protein phosphatase binding
- F-box-like
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lymphoblastic leukemia
- colorectal cancer
- acute myeloid leukemia
- hypertension
role in cell
- growth
- expression in
- apoptosis
- phosphorylation in
- migration
- differentiation
- proliferation
- quantity
- G2/M phase
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- regulation of protein kinase B signaling cascade
- regulation of autophagy
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of inflammatory response
- protein monoubiquitination
- negative regulation of NLRP3 inflammasome complex assembly
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- protein phosphatase binding