SERPINB4 Gene Summary [Human]
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB4 |
| Official Name | serpin family B member 4 [Source:HGNC Symbol;Acc:HGNC:10570] |
| Ensembl ID | ENSG00000206073 |
| Bio databases IDs | |
| Aliases | serpin family B member 4 |
| Synonyms | LEUPIN, PI11, SCCA1, SCCA-2, serpin family B member 4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- enzyme binding
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- psoriasis
- squamous-cell carcinoma
- squamous cell cancer
- cholesteatoma
- adenocarcinoma
- plaque psoriasis
- epidermal hyperplasia
- eczema
- delayed hypersensitive reaction
role in cell
- phosphorylation in
- apoptosis
- survival
- protection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protection from natural killer cell mediated cytotoxicity
- regulation of proteolysis
- negative regulation of endopeptidase activity
- negative regulation of peptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protease binding
- enzyme binding