GPR15 Gene Summary [Human]
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | GPR15 |
| Official Name | G protein-coupled receptor 15 [Source:HGNC Symbol;Acc:HGNC:4469] |
| Ensembl ID | ENSG00000154165 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 15 |
| Synonyms | 4933439K08RIK, BOB, G protein-coupled receptor 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- viral receptor
- cytoplasmic domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- coreceptor
Pathways
Biological processes and signaling networks where the GPR15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- Endoplasmic Reticulum
- trans Golgi network
- cis Golgi networks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- G-protein coupled receptor signaling pathway
- angiogenesis
- T cell migration
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- G-protein coupled receptor activity
- protein binding
- viral receptor activity