LEF1 Gene Summary [Human]
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | LEF1 |
| Official Name | lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551] |
| Ensembl ID | ENSG00000138795 |
| Bio databases IDs | |
| Aliases | lymphoid enhancer binding factor 1 |
| Synonyms | 3000002B05, lymphoid enhancer binding factor 1, TCF10, TCF1ALPHA, TCF7L3, TCF/LEF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LEF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription activation domain
- transcription factor binding
- chromatin binding
- estrogen receptor binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- N-terminal CTNNB1 binding
- HMG (high mobility group) box
- beta-catenin binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- histone binding
- DNA binding domain
- nucleic acid binding
- beta-catenin binding
- VWRPY domain
- high mobility group (HMG)-box domain superfamily
- nuclear localization sequence
- histone deacetylase binding
- DNA bending protein
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- gamma-catenin binding
- double-stranded DNA binding
- context-dependent activation domain
- HMG-box domain
- high mobility group
- Box B domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the LEF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Basal Cell Carcinoma Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endometrial Cancer Signaling
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- ILK Signaling
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Opioid Signaling Pathway
- Ovarian Cancer Signaling
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Thyroid Cancer Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- neoplasia
- tumorigenesis
- basal cell skin cancer
role in cell
- binding in
- recruitment in
- apoptosis
- expression in
- proliferation
- survival
- activation in
- cell death
- formation in
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- nucleoplasm
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LEF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sprouting angiogenesis
- transcription from RNA polymerase II promoter
- tongue development
- face morphogenesis
- negative regulation of striated muscle tissue development
- cell chemotaxis
- forebrain neuroblast division
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- neutrophil differentiation
- anatomical structure regression
- B cell proliferation
- formation of radial glial scaffolds
- chorio-allantoic fusion
- dentate gyrus development
- forebrain radial glial cell differentiation
- T-helper 1 cell differentiation
- positive regulation of granulocyte differentiation
- negative regulation of interleukin-4 production
- negative regulation of interleukin-5 production
- somitogenesis
- protein localization to chromatin
- positive regulation of gene expression
- epithelial to mesenchymal transition
- positive regulation of Wnt receptor signaling pathway
- regulation of neurogenesis
- positive regulation of cell migration
- positive regulation by host of viral transcription
- trachea gland development
- positive regulation of gamma-delta T cell differentiation
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- paraxial mesoderm formation
- embryonic limb morphogenesis
- patterning of blood vessels
- cellular response to interleukin-4
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- sensory perception of taste
- T cell receptor V(D)J recombination
- positive regulation of cell differentiation
- regulation of transcription from RNA polymerase II promoter
- mammary gland development
- negative regulation of apoptotic process
- positive regulation of cell proliferation in bone marrow
- negative regulation of interleukin-13 production
- cellular response to cytokine stimulus
- negative regulation of apoptotic process in bone marrow
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- DNA binding, bending
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription corepressor binding
- gamma-catenin binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone binding
- armadillo repeat domain binding
- C2H2 zinc finger domain binding
- estrogen receptor binding