LY96 Gene Summary [Human]
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | LY96 |
| Official Name | lymphocyte antigen 96 [Source:HGNC Symbol;Acc:HGNC:17156] |
| Ensembl ID | ENSG00000154589 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 96 |
| Synonyms | ESOP-1, lymphocyte antigen 96, MD-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LY96 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- N-linked glycosylation site
- ML
- hydrophilic domain
- ML domain
- protein binding
- transmembrane receptor
- coreceptor
- hydrophobic domain
Pathways
Biological processes and signaling networks where the LY96 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- ulcerative colitis
- rheumatoid arthritis
- endometriosis
- severe sepsis
- neonatal late-onset sepsis
- septic shock
- ischemic stroke
- colitis
- acute respiratory distress syndrome
role in cell
- phosphorylation in
- expression in
- invasion by
- migration
- proliferation
- production in
- activation in
- binding in
- recruitment
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- Golgi Apparatus
- Endoplasmic Reticulum
- membrane compartment
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LY96 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 4 signaling pathway
- cell surface receptor signaling pathway
- toll-like receptor signaling pathway
- cellular defense response
- inflammatory response
- cellular response to lipopolysaccharide
- innate immune response
- lipopolysaccharide-mediated signaling pathway
- response to lipopolysaccharide
- positive regulation of tumor necrosis factor production
- detection of lipopolysaccharide
- positive regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- lipopolysaccharide receptor complex
- receptor complex
- endosome membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- Toll-like receptor 4 binding
- lipopolysaccharide receptor activity
- protein binding
- lipopolysaccharide binding