HSPA13 Gene Summary [Human]
The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HSPA13 |
| Official Name | heat shock protein family A (Hsp70) member 13 [Source:HGNC Symbol;Acc:HGNC:11375] |
| Ensembl ID | ENSG00000155304 |
| Bio databases IDs | |
| Aliases | heat shock protein family A (Hsp70) member 13 |
| Synonyms | 1600002I10Rik, B230217N24Rik, heat shock protein 70 family, member 13, heat shock protein family A (Hsp70) member 13, STCH, STRESS 70 protein CHAPERONE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSPA13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase domain
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HSPA13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Mitochondria
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSPA13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone mediated protein folding requiring cofactor
- protein refolding
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- heat shock protein binding
- protein binding
- protein binding involved in protein folding