RASA2 Gene Summary [Human]
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RASA2 |
| Official Name | RAS p21 protein activator 2 [Source:HGNC Symbol;Acc:HGNC:9872] |
| Ensembl ID | ENSG00000155903 |
| Bio databases IDs | |
| Aliases | RAS p21 protein activator 2, Ras GTPase-activating protein 2 |
| Synonyms | 5430433H21RIK, AU023900, GAP1M, RAS p21 protein activator 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- GTPase-activator protein for Ras-like GTPase
- BTK motif
- PH domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- metabolic syndrome X
- breast carcinoma
- early missed abortion
- Noonan syndrome
- Noonan syndrome type 1
role in cell
- activation in
- proliferation
- growth
- killing
- phagocytosis by
- killing by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- phospholipid binding