MRAS Gene Summary [Human]

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Details

Type
Protein Coding
Official Symbol
MRAS
Official Name
muscle RAS oncogene homolog [Source:HGNC Symbol;Acc:HGNC:7227]
Ensembl ID
ENSG00000158186
Bio databases IDs NCBI: 22808 Ensembl: ENSG00000158186
Aliases muscle RAS oncogene homolog
Synonyms 2900078C09RIK, muscle and microspikes RAS, muscle RAS oncogene homolog, NS11, Ras3, R-RAS3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRAS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • GTP binding domain
  • GTP-dependent protein binding
  • membrane-association domain
  • Small GTPase of the Ras superfamily (ill-defined subfamily)
  • Ras family
  • GTPase
  • enzyme
  • protein binding
  • effector domain
  • Ras subfamily of RAS small GTPases
  • CAAX box
  • small GTP-binding protein domain
  • Rab subfamily of small GTPases
  • Ras of Complex, Roc, domain of DAPkinase
  • Rho (Ras homology) subfamily of Ras-like small GTPases
  • P-loop containing Nucleoside Triphosphate Hydrolases

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • coronary artery disease
  • non-insulin-dependent diabetes mellitus
  • Noonan syndrome type 11
  • nonalcoholic steatohepatitis
  • myocardial infarction
  • Noonan spectrum disorder
  • Noonan syndrome
  • cardiovascular disorder
  • sporadic amyotrophic lateral sclerosis
regulated by
regulates
role in cell
  • migration
  • expression in
  • proliferation
  • binding in
  • apoptosis
  • survival
  • quantity
  • formation
  • growth
  • epithelial-mesenchymal transition

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • membrane fraction
  • Cytoplasm
  • cellular membrane
  • Endoplasmic Reticulum
  • membrane ruffles
  • pseudopodia
  • microspikes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MRAS gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • Ras protein signal transduction
  • actin cytoskeleton organization

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • GTP binding
  • protein binding
  • GTPase activity
  • small monomeric GTPase activity
  • GDP binding
  • GTP-dependent protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.