DCK Gene Summary [Human]
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DCK |
| Official Name | deoxycytidine kinase [Source:HGNC Symbol;Acc:HGNC:2704] |
| Ensembl ID | ENSG00000156136 |
| Bio databases IDs | |
| Aliases | deoxycytidine kinase |
| Synonyms | dCyd Kinase, deoxycytidine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside kinase
- ATP binding
- nuclear localization sequence
- protein binding
- deoxycytidine kinase
- magnesium ion binding
- deoxyadenosine kinase
- deoxyguanosine kinase
- kinase
- binding protein
- NK
- alcohol group acceptor phosphotransferase
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- acute lymphoid leukemia in remission
- multiple sclerosis
- grade 3b follicular lymphoma
- acute myeloid leukemia
- refractory diffuse large B-cell lymphoma
- diffuse large B-cell lymphoma associated with chronic inflammation
- B-cell lymphoma
- primary mediastinal large B-cell lymphoma
- leukemia
role in cell
- expression in
- apoptosis
- cell death
- quantity
- differentiation
- cell cycle progression
- number
- proliferation
- cell viability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- mitochondrial membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CMP biosynthetic process
- pyrimidine nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- deoxyguanosine kinase activity
- ATP binding
- protein homodimerization activity
- cytidine kinase activity
- deoxycytidine kinase activity
- deoxyadenosine kinase activity