MED19 Gene Summary [Human]
The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | MED19 |
| Official Name | mediator complex subunit 19 [Source:HGNC Symbol;Acc:HGNC:29600] |
| Ensembl ID | ENSG00000156603 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 19 |
| Synonyms | 2410018M14RIK, 3110040A13Rik, DT2P1G7, LCMR1, MED19AS, mediator complex subunit 19, RGD1311926 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MED19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator of RNA pol II transcription subunit 19
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MED19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription factor binding