MOCS3 Gene Summary [Human]
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | MOCS3 |
| Official Name | molybdenum cofactor synthesis 3 [Source:HGNC Symbol;Acc:HGNC:15765] |
| Ensembl ID | ENSG00000124217 |
| Bio databases IDs | |
| Aliases | molybdenum cofactor synthesis 3, ubiquitin-like modifier activating enzyme 4, UBA4, ubiquitin-activating enzyme E1 homolog (yeast) |
| Synonyms | 1700020H17RIK, molybdenum cofactor synthesis 3, UBA4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MOCS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- molybdopterin-synthase adenylyltransferase
- sulfurtransferase
- thiazole biosynthesis adenylyltransferase ThiF, E
- nucleotidyltransferase
- Rhodanese Homology Domain
- URM1 activating enzyme
- enzyme
- molybdopterin synthase sulfurtransferase
- protein binding
- Rhodanese-like domain
- RHOD
- MoeBD
- ThiF family
- E1_enzyme_family
Pathways
Biological processes and signaling networks where the MOCS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MOCS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA wobble uridine modification
- molybdopterin cofactor metabolic process
- tRNA wobble position uridine thiolation
- protein urmylation
- Mo-molybdopterin cofactor biosynthetic process
- tRNA thio-modification
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nucleotidyltransferase activity
- protein binding
- URM1 activating enzyme activity
- metal ion binding
- sulfurtransferase activity
- thiosulfate sulfurtransferase activity