VPS8 Gene Summary [Human]
Predicted to enable metal ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | VPS8 |
| Official Name | VPS8 subunit of CORVET complex [Source:HGNC Symbol;Acc:HGNC:29122] |
| Ensembl ID | ENSG00000156931 |
| Bio databases IDs | |
| Aliases | VPS8 subunit of CORVET complex |
| Synonyms | KIAA0804, mKIAA0804, RGD1309443, VPS8 CORVET complex subunit, VPS8 subunit of CORVET complex |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- Golgi CORVET complex core vacuolar protein 8
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- endosomal vesicle fusion
- protein targeting to vacuole
Cellular Component
Where in the cell the gene product is active
- early endosome
- CORVET complex
- late endosome
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding