ALDH3A2

ALDH3A2 Gene Summary

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
ALDH3A2
Official Name
aldehyde dehydrogenase 3 family member A2 [Source:HGNC Symbol;Acc:HGNC:403]
Ensembl ID
ENSG00000072210
Bio databases IDs NCBI: 224 Ensembl: ENSG00000072210
Aliases aldehyde dehydrogenase 3 family member A2, fatty aldehyde dehydrogenase
Synonyms
ALD10,aldehyde dehydrogenase 3 family member A2,aldehyde dehydrogenase 3 family, member A2,ALDH10,Aldh4,FALDH,SLS
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Aldehyde dehydrogenase family
  • Acyl-CoA reductase (LuxC)
  • aldehyde dehydrogenase (NAD)
  • long-chain-aldehyde dehydrogenase
  • aldehyde dehydrogenase
  • long-chain-alcohol oxidase
  • phenylacetaldehyde dehydrogenase
  • protein homodimerization
  • enzyme
  • protein binding
  • methylmalonic acid semialdehyde dehydrogenase
  • NAD(P)+-dependent aldehyde dehydrogenase superfamily

Pathways

Biological processes and signaling networks where the ALDH3A2 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • RTN4
  • RCCD1
  • CNR2
  • MMS19
  • EGFR
  • ATR
  • BRD7
  • DNAJC14
  • SEC63
  • IPO13
disease
  • diabetic nephropathy
  • delayed hypersensitive reaction
  • Sjögren-Larsson syndrome
  • psoriasis
  • aortic valve calcification
  • preeclampsia
  • oral leukoplakia
  • oral lichen planus
regulated by
  • PPARA
  • beta-estradiol
  • medroxyprogesterone acetate
  • CGA
  • n-nitrosomethylbenzylamine
  • tretinoin
  • TGFB1
  • tamoxifen
  • methylprednisolone
  • black raspberry extract
regulates
  • ceramide
  • reactive oxygen species
  • d18:1/48:3 omega-O-linoleoyl-ceramide
  • long-chain aldehyde
  • d18:1/52:2 omega-O-linoleoyl-ceramide
  • d18:1/50:2 omega-O-linoleoyl-ceramide
  • aldehyde
  • geranylgeranial
  • formaldehyde
  • d18:1/54:2 omega-O-linoleoyl-ceramide
role in cell
  • response

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • cellular membrane
  • Endoplasmic Reticulum
  • cytosol
  • endoplasmic reticulum membrane
  • peroxisome membrane
  • peroxisomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ALDH3A2 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • cellular aldehyde metabolic process
  • central nervous system development
  • epidermis development
  • hexadecanal metabolic process
  • peripheral nervous system development
  • phytol metabolic process
  • fatty acid metabolic process

CELLULAR COMPONENT

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • peroxisomal membrane
  • cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • aldehyde dehydrogenase (NAD) activity
  • glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
  • 3-chloroallyl aldehyde dehydrogenase activity
  • protein homodimerization activity
  • protein binding
  • medium-chain-aldehyde dehydrogenase activity
  • long-chain-alcohol oxidase activity
  • long-chain-aldehyde dehydrogenase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.