KIF5B Gene Summary [Human]
Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of protein localization to plasma membrane. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF5B |
| Official Name | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] |
| Ensembl ID | ENSG00000170759 |
| Bio databases IDs | |
| Aliases | kinesin family member 5B, ubiquitous kinesin heavy chain |
| Synonyms | HEL-S-61, Khc, Khc-b, Khcs, KINESIN 1, KINESIN 1 HEAVY CHAIN, kinesin family member 5B, KINH, KNS, KNS1, UKHC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF5B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Actin interacting protein 3
- Myosin and Kinesin motor domain
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- coiled-coil domain
- JUN kinase binding
- protein binding
- motor domain
- identical protein binding
- microtubule motor protein
- Kinesin motor, catalytic domain
- microtubule binding
- binding protein
- stalk region
- Kinesin motor domain
- tail domain
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- middle stalk coils
- cargo binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- myeloid/lymphoid neoplasm with eosinophilia
- hematological neoplasia
- osteogenesis imperfecta
- passive systemic anaphylaxis
- hypertrophic cardiomyopathy
- bipolar disorder
- habitual abortion
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- aggregation in
- formation
- transmembrane potential
- maturation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- microtubule cytoskeleton
- axon component
- organelle
- perinuclear region
- vesicles
- centrosome
- Mitochondria
- cytosol
- ciliary rootlet
- nuclear envelope
- growth cone
- neurites
- endocytotic vesicle
- beta-granules
- axons
- dendrites
- phagosomes
- mossy fibers
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF5B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- axon guidance
- positive regulation of potassium ion transport
- natural killer cell mediated cytotoxicity
- microtubule-based movement
- cytoplasm organization
- centrosome localization
- lysosome localization
- plus-end-directed vesicle transport along microtubule
- regulation of membrane potential
- stress granule disassembly
- synaptic vesicle transport
- mitochondrion transport along microtubule
- vesicle transport along microtubule
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- perinuclear region of cytoplasm
- centriolar satellite
- dendrite cytoplasm
- mitochondrion
- membrane
- phagocytic vesicle
- cytosol
- vesicle
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- microtubule motor activity
- protein binding
- cadherin binding
- plus-end-directed microtubule motor activity
- microtubule binding