VIPR2 Gene Summary [Human]
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | VIPR2 |
| Official Name | vasoactive intestinal peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:12695] |
| Ensembl ID | ENSG00000106018 |
| Bio databases IDs | |
| Aliases | vasoactive intestinal peptide receptor 2, VIP and PACAP receptor 2 |
| Synonyms | C16DUPq36.3, DUP7q36.3, LOC100862566, PACAP-R-3, PVR3, SCZD16, vasoactive intestinal peptide receptor 2, Vip2, VPAC2, VPAC2R, Vpac2 receptor, VPCAP2R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VIPR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- transmembrane domain
- intracellular domain
- seven-transmembrane G protein-coupled receptor superfamily
- pituitary adenylate cyclase activating protein receptor
- vasoactive intestinal polypeptide receptor
Pathways
Biological processes and signaling networks where the VIPR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pathologic myopia
- refractive error
- myopia
- corneal astigmatism
- hypersensitivity reaction type I
- gastroesophageal reflux
- anaphylaxis
- rheumatoid arthritis
- delayed hypersensitive reaction
- ischemic stroke
role in cell
- migration
- expression in
- apoptosis
- differentiation
- proliferation
- activation
- production in
- quantity
- activation-induced cell death
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VIPR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of smooth muscle cell proliferation
- cell-cell signaling
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- vasoactive intestinal polypeptide receptor activity
- peptide hormone binding