Vps8 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Part of CORVET complex. Is expressed in cranial ganglion; dorsal root ganglion; and neural retina. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps8 |
| Official Name | VPS8 CORVET complex subunit [Source:MGI Symbol;Acc:MGI:2146407] |
| Ensembl ID | ENSMUSG00000033653 |
| Bio databases IDs | |
| Aliases | VPS8 CORVET complex subunit |
| Synonyms | KIAA0804, mKIAA0804, RGD1309443, VPS8 CORVET complex subunit, VPS8 subunit of CORVET complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- Golgi CORVET complex core vacuolar protein 8
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of SNARE complex assembly
- endosomal vesicle fusion
- protein targeting to vacuole
Cellular Component
Where in the cell the gene product is active
- early endosome
- CORVET complex
- late endosome
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding