ZFYVE9 Gene Summary [Human]
This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | ZFYVE9 |
| Official Name | zinc finger FYVE-type containing 9 [Source:HGNC Symbol;Acc:HGNC:6775] |
| Ensembl ID | ENSG00000157077 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 9, protein phosphatase 1, regulatory subunit 173 |
| Synonyms | E030027L17, hSARA, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger, FYVE domain containing 9, zinc finger FYVE-type containing 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFYVE9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- SMAD binding
- smad binding domain
- peptidase
- protein domain specific binding
- enzyme
- protein binding
- phosphatidylinositol binding
- FYVE domain like superfamily
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- Domain of unknown function (DUF3480)
- Smad anchor for receptor activation (SARA)
Pathways
Biological processes and signaling networks where the ZFYVE9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteogenesis imperfecta type III
- chronic epilepsy
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- expression in
- binding in
- morphology
- ubiquitination in
- size
- aggregation
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- vesicles
- cytosol
- microdomains
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFYVE9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transforming growth factor beta receptor signaling pathway
- endosomal transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- metal ion binding
- 1-phosphatidylinositol binding