Zfyve9 Gene Summary [Mouse]
Predicted to enable 1-phosphatidylinositol binding activity; SMAD binding activity; and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfyve9 |
| Official Name | zinc finger, FYVE domain containing 9 [Source:MGI Symbol;Acc:MGI:2652838] |
| Ensembl ID | ENSMUSG00000034557 |
| Bio databases IDs | |
| Aliases | zinc finger, FYVE domain containing 9 |
| Synonyms | E030027L17, hSARA, MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger, FYVE domain containing 9, zinc finger FYVE-type containing 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfyve9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- SMAD binding
- smad binding domain
- peptidase
- protein domain specific binding
- enzyme
- protein binding
- phosphatidylinositol binding
- FYVE domain like superfamily
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- Domain of unknown function (DUF3480)
- Smad anchor for receptor activation (SARA)
Pathways
Biological processes and signaling networks where the Zfyve9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteogenesis imperfecta type III
- chronic epilepsy
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- expression in
- binding in
- morphology
- ubiquitination in
- size
- aggregation
- enlargement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- vesicles
- cytosol
- microdomains
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfyve9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transforming growth factor beta receptor signaling pathway
- endosomal transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- intracellular membrane-bounded organelle
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- metal ion binding
- 1-phosphatidylinositol binding