PIK3C2A

PIK3C2A Gene Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
PIK3C2A
Official Name
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [Source:HGNC Symbol;Acc:HGNC:8971]
Ensembl ID
ENSG00000011405
Bio databases IDs NCBI: 5286 Ensembl: ENSG00000011405
Aliases phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms
CPK,Cpk-m,OCSKD,p170 Pi3-kinase,phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha,phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha,phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 α,phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 α,PI3KC2,PI3-K-C2A,PI3-K-C2(ALPHA),PI3K-C2-alpha,PI3-K-C2(α),PI3K-C2-α
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • activation domain
  • clathrin binding domain
  • Phosphatidylinositol 3- and 4-kinase
  • phosphatidylinositol-4,5-bisphosphate 3-kinase
  • clathrin binding
  • PI3-kinase family, ras-binding domain
  • PI3Ka
  • kinase
  • phosphatidylinositol 3-kinase
  • phosphatidylinositol-4-phosphate 3-kinase
  • Phosphoinositide 3-kinase, catalytic domain
  • Protein Kinases, catalytic domain
  • The Phox Homology domain, a phosphoinositide binding module
  • Protein kinase C conserved region 2 (CalB)
  • PX domain
  • C2 domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • EGFR
  • CNOT9
  • ANKFY1
  • MYO1C
  • STAMBP
  • YWHAB
  • FUS
  • DNAJA2
  • YWHAZ
  • CLTB
disease
  • renal clear cell adenocarcinoma
  • insomnia
  • chronic stable angina
  • bipolar disorder
  • oculoskeletodental syndrome
  • schizophrenia
  • arterial occlusive disease
  • disease-free survival
  • renal clear cell cancer
  • acute coronary syndrome
regulated by
  • AGT
  • beta-estradiol
  • AGTR1
  • CCL2
  • Caco2 cells
  • Immunoglobulin
  • insulin
  • tretinoin
  • KIF15
  • RHOQ
regulates
  • RHOA
  • KDR
  • AKT1
  • phosphatidylinositol
  • phosphatidylinositol 4-phosphate
  • MSN
  • phosphatidylinositol 3,4-bisphosphate
  • filamin
  • MTORC1
  • SLC2A4
role in cell
  • growth
  • phosphorylation in
  • expression in
  • migration
  • activation in
  • proliferation
  • survival
  • stabilization in
  • organization
  • response

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • nuclear fraction
  • plasma membrane/trans-Golgi network fraction
  • low-density microsomal fraction
  • intracellular membrane-bounded organelle
  • perinuclear region
  • Nucleus
  • Plasma Membrane
  • vesicles
  • Golgi Apparatus
  • cytosol
  • trans Golgi network
  • nucleoplasm
  • nuclear speckles
  • clathrin-coated pits
  • clathrin-coated vesicles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PIK3C2A gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • membrane organization
  • insulin receptor signaling pathway
  • epidermal growth factor receptor signaling pathway
  • phosphatidylinositol-3-phosphate biosynthetic process
  • platelet-derived growth factor receptor signaling pathway
  • phosphatidylinositol biosynthetic process
  • endocytosis
  • positive regulation of cell migration involved in sprouting angiogenesis
  • exocytosis
  • positive regulation of autophagy
  • protein kinase B signaling cascade
  • clathrin coat assembly
  • vascular smooth muscle contraction
  • phosphatidylinositol-mediated signaling
  • cell migration

CELLULAR COMPONENT

Where in the cell the gene product is active
  • phosphatidylinositol 3-kinase complex
  • trans-Golgi network
  • extracellular vesicular exosome
  • cytoplasm
  • intracellular membrane-bounded organelle
  • membrane
  • vesicle
  • cytosol
  • clathrin-coated vesicle
  • plasma membrane
  • nucleoplasm

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • ATP binding
  • phosphatidylinositol binding
  • clathrin binding
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
  • 1-phosphatidylinositol-4-phosphate 3-kinase activity
  • 1-phosphatidylinositol-3-kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.