ST3GAL2 Gene Summary [Human]
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ST3GAL2 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10863] |
| Ensembl ID | ENSG00000157350 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| Synonyms | Gal-NAc6S, Sialyltransferase 5, SIAT4B, Siat5, ST3 beta-galactoside alpha-2,3-sialyltransferase 2, ST3GalA.2, ST3GALII, ST3 β-galactoside α-2,3-sialyltransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST3GAL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- sialyltransferase
- protein homodimerization
- enzyme
- monosialoganglioside sialyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
regulates
- lipid
- ganglioside GT1
- glycoprotein
- glycosphingolipid
- oligosaccharide
- keratan sulfate
- O-glycan
- glycolipid
role in cell
- proliferation
- quantity
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST3GAL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- globoside biosynthetic process via lactosylceramide
- viral protein processing
- ganglioside biosynthetic process via lactosylceramide
- glycoprotein biosynthetic process
- protein glycosylation
- glycolipid biosynthetic process
- oligosaccharide biosynthetic process
- keratan sulfate biosynthetic process
- O-glycan processing
- glycosphingolipid biosynthetic process
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- monosialoganglioside sialyltransferase activity
- sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity